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This is due to the fact that the drug slows your metabolism. 1) Even if you maintained the same diet and exercise patterns pre-drug that you did while taking Seroquel, you’d probably still gain some weight. Though if you are vigilant about your eating and activity habits, you can minimize this issue (This does not have any scientific support at the moment, but it doesn’t hurt to try. Motivational deficits: For some people, Seroquel can decrease motivation and lead to sleepiness or grogginess. 08 kg for 200 to 399 mg/day, 1. According to E Med TV, about 23 percent of Seroquel users experience weight gain of 7 percent or more of their original body weight. 89 kg for 400 to 599 mg/day, and 3. The Seroquel dosesare the main factors that influence weight changes. Choose low-calorie foods like fresh fruits and vegetables, eat fiber-rich and slow-to-digest complex carbohydrates, and drink lots of. I am already very self conscious about my weight, and currently sit at about 235lbs. 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